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pentobarbital will lessen the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Double brexpiprazole dose above one-two weeks if administered with a solid CYP3A4 inducer.pentobarbital will decrease the extent or outcome of darunavir by affecting hepatic/intestinal enzym